2-(3-Bromopropyl)isoindoline-1,3-dione
نویسندگان
چکیده
In the title compound, C(11)H(10)BrNO(2), the dihedral angle between the five- and six-membered rings of the phthalamide system is 1.00 (16)°. There are no significant inter-molecular inter-ations except for van der Waals contacts.
منابع مشابه
2-(2-Fluoro-4-hydroxybenzyl)isoindoline-1,3-dione
In the title compound, C(15)H(10)FNO(3), the dihedral angle between the isoindoline-1,3-dione and 3-fluoro-4-methyl-phenol groups is 86.88 (8)°. The isoindoline-1,3-dione fragment is almost planar, with an r.m.s. deviation of 0.0154 Å within the group. Inter-molecular C-H⋯O hydrogen bonds generate C(6) chains running parallel to the [010] direction.
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A green and convenient protocol is described for the preparation of E-1-(alkylamino)-3- (1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl viaone-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an E-cinnamic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there is no side produ...
متن کاملThe three-component reaction of 2-(2-oxopropyl)isoindoline-1,3-dione with alkyl isocyanides and aromatic carboxylic acids under catalyst-free conditions in water
A green and convenient protocol is described for the preparation of 1-(alkylamino)-3-(1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl benzoates via one-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an aromatic carboxylic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there...
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In the title compound, C(12)H(7)NO(5), the dihedral angle between the isoindole-1,3-dione plane and the least-squares plane of the furan ring is 89.2 (2)°. In the crystal structure, mol-ecules are linked through inter-molecular C-H⋯O hydrogen bonds, forming centrosymmetric dimers.
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Sixteen new phthalimide derivatives were synthesized and evaluated for their in vitro anti-microbial, anti-oxidant and anti-inflammatory activities. The cytotoxicity for all synthesized compounds was also determined in cancer cell lines and in normal human cells. None of the target derivatives had any cytotoxic activity. (ZE)-2-[4-(1-Hydrazono-ethyl) phenyl]isoindoline-1,3-dione (12) showed rem...
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